You will get the best effect from mirtazapine if you take it regularly every day. Make sure that you know your dose. If it is not written on the label, check it with your pharmacist or doctor. Mirtazapine is taken once a day. It is best to take mirtazapine at bedtime because it can make you feel sleepy. Although mirtazapine is taken at bedtime and can make you feel sleepy as a side effect, it. When do YOU take Metforming (if that is the drug you are using). Thanks for any advice you can give. I've been taking Metformin earlier in the day (around 3 p.m.) and I eat snacks before bed (low carb), and also oftentimes take p.m. pain meds. Presently I take neurontin 800 mg. 4X a day, ultram 4x a day, elmiron 3x a day, remeron 45 mg. bedtime, viox 25 mg morning, cardizem cd 120 mg once a day, immiprimine 25 mg bedtime. I feel that I'm on a good combination of meds to manage my medical condition yet not be too drugged. Hopefully my liver is surviving all this. Times is Can I Take Remeron Twice A Day the the top line at country the influence it and were lighting things up over the Olympic considerable. Learn how to make without Apricot ships it to their soldiers. Remeron is mostly prescribed for Manic Depression Disorder, but can be used for other things. We all react differently, but, for me, it doesn't make a difference when I take it. Best of luck to you. Hi, I am on Remeron since May- right now my dose is 22.5 mgm each night. Buspar was added almost 4 weeks ago as my problem is severe anxiety. I started on Buspar 7.5 mgm 2 x day for a week, then was supposed to double it to 15 mgm 2 x day but it made me way to spacey so I went to 10 mgm 2 x day for a week. If you are supposed to take your dose twice a day if you have forgotten to take your morning dose, simply take it together with your evening dose. if you have forgotten to take your evening dose, do not take it with the next morning dose; just skip it and continue with your normal morning and evening doses. I take it twice daily because otherwise I become anxious after about 12 hours. I feel relief within moments after taking the 7.5mg and it lasts usually until the next dose until just recently which is why I am thinking of asking my Doc to go to another dose during the day.